Contributing to the pancreatic function, Human Pancreatic Epithelial Cells line the pancreatic ducts. They synthesize and release digestive enzymes and bicarbonate to assist in the digestive process and reduce stomach acidity. They are particularly valuable in cancer research owing to their transformation into pancreatic cancer. They are the in vitro tools to study the cancerous transformation, identify the oncogenes, and analyze the effect of carcinogens on cancer development. Additionally, they are also present at the core of other diseases, such as pancreatitis and cystic fibrosis, emphasizing their role in the pancreas.
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